Anatomic Line Cryogel Muscle & Joint Pain Relief Gel for Back, Neck & Shoulders Ache 100ml
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Memic, A.; Rezaeeyazdi, M.; Villard, P.; Rogers, Z.J.; Abudula, T.; Colombani, T.; Bencherif, S.A. Effect of Polymer Concentration on Autoclaved Cryogel Properties. Macromol. Mater. Eng. 2020, 305, 1900824. [ Google Scholar] [ CrossRef]
permission is required to reuse all or part of the article published by MDPI, including figures and tables. For in a third-party publication (excluding your thesis/dissertation for which permission is not required) R. Gellert, Inorganic mineral materials for insulation in buildings, in Materials for Energy Efficiency and Thermal Comfort in Buildings, Elsevier, 2010, pp. 193–228 Search PubMed .Wartenberg, A.; Weisser, J.; Schnabelrauch, M. Glycosaminoglycan-Based Cryogels as Scaffolds for Cell Cultivation and Tissue Regeneration. Molecules 2021, 26, 5597. [ Google Scholar] [ CrossRef] T. Y. Wei, T. F. Chang, S. Y. Lu and Y. C. Chang, Preparation of monolithic silica aerogel of low thermal conductivity by ambient pressure drying, J. Am. Ceram. Soc., 2007, 90(7), 2003–2007 CrossRef CAS .
Abudula, T.; Saeed, U.; Al-Turaif, H.; Alshahrie, A. Homogenous Microporous Hollow Nano Cellulose Fibril Reinforced PLA/PBS Scaffolds for Tissue Engineering. U.S. Patent 11103617B1, 31 August 2021. [ Google Scholar] Three-dimensional scaffolds that exhibit a highly porous architecture could be very useful for several biomedical applications especially in tissue engineering 1, 75. Macroporous cryogels have been made from a variety of natural polymers meant to recapitulate the composition and structural properties of the ECM 1, 37, 44. For example, by varying the polymerization temperature and cooling rate 87, the mechanical properties of cryogels could be tuned to match those of the native tissues. Similarly, injectable cryogels with improved mechanical properties compared to their hydrogel counterparts can be fabricated 87, 88. However, microbial infections remain a major challenge associated with scaffolds and biomedical implants. Specifically, in clinical orthopedics, complications related to pathogenic bacterial colonization represent a major barrier to tissue repair and healing 89. Although various approaches have been explored to confer hydrogels with antimicrobial properties, they have been associated with a number of limitations, including cytotoxicity and poor tissue integration 90, 91, 92. Here, we report the fabrication of multifunctional cryogels (i.e., needle-injectable, biodegradable, and with antimicrobial activity) that could improve current strategies for developing scaffolds for tissue engineering.Su, E.; Okay, O. Cryogenic formation-structure-property relationships of poly(2-acrylamido-2-methyl-1-propanesulfonic acid) cryogels. Polymer 2019, 178, 121603. [ Google Scholar] [ CrossRef]
Cryogels comprising the natural biopolymers silk fibroin and chitosan, with tannic acid and ferric ions (Fe 3+) incorporated have been reported as multifunctional devices for wound healing providing hemostasis, exudate absorbance, antibacterial effects, and promotion of cell proliferation [ 117]. The tannic acid and ferric ions provide photothermal properties whereby under near infrared (NIR) radiation the temperature increased to enhance the antimicrobial properties, while also showing good hemostasis properties such as blood absorption and clotting, and cell proliferation. Chitosan has also been used by Meena et al. for producing cryogels for haemostatic applications, with locust bean gum (LBG) incorporated to enhance mechanical properties and water absorption [ 32]. This chitosan/LBG semi-interpenetrating network cryogel was investigated for its swelling, degradation, and protein adsorption properties, demonstrating potential as a haemostatic dressing. Hixon, K.R.; Eberlin, C.T.; Kadakia, P.U.; McBride-Gagyi, S.H.; Jain, E.; Sell, S.A. A comparison of cryogel scaffolds to identify an appropriate structure for promoting bone regeneration. Biomed. Phys. Eng. Express 2016, 2, 035014. [ Google Scholar] [ CrossRef] Kundu, B.; Kundu, S.C. Bio-inspired fabrication of fibroin cryogels from the muga silkworm Antheraea assamensis for liver tissue engineering. Biomed. Mater. 2013, 8, 055003. [ Google Scholar] [ CrossRef] [ PubMed]J. Rouquerol, D. Avnir, C. Fairbridge, D. Everett, J. Haynes, N. Pernicone, J. Ramsay, K. Sing and K. Unger, Recommendations for the characterization of porous solids (Technical Report), Pure Appl. Chem., 1994, 66(8), 1739–1758 CrossRef CAS . Bhat, S.; Kumar, A. Biomaterials and bioengineering tomorrow’s healthcare. Biomatter 2013, 3, e24717. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version]